American geneticist

Elaine R. Mardis (born September 28, 1962) is the co-executive director of the Ins*ute for Genomic Medicine at Nationwide Children's Hospital, where she also serves as the Nationwide Foundation Endowed Chair in Genomic Medicine. She also is professor of pediatrics at the Ohio State University College of Medicine. Mardis’s research focuses on the genomic characterization of cancer and its implications for cancer medicine. She was part of the team that reported the first next-generation-based sequencing of a whole cancer genome, and participated extensively in The Cancer Genome Atlas (TCGA) and the Pediatric Cancer Genome Project (PCGP).

Contents

• 1 Biography
• 2 Awards and honors
• 3 References
• 4 External links

Biography

Mardis was born in North Platte, Nebraska. She gained a p*ion for science at an early age, and credits her father, a chemistry professor for more than 30 years, for nurturing this p*ion.

She received her undergraduate degree in Zoology from the University of Oklahoma in 1984. During her senior year she took a course in biochemistry that was taught by Bruce Roe, PhD, which says opened her eyes to the world of molecular biology. She stayed at the University of Oklahoma for her doctoral studies under the supervision of Dr. Roe, who was one of the first academic scientists to have a fluorescent DNA sequencer in the laboratory. As a result, during her doctoral work Mardis learned the art of DNA sequencing, at a time when few others were doing this.

After obtaining her PhD in chemistry and biochemistry in 1989, Mardis did postgraduate work in industry at Bio-Rad Laboratories in Hercules, California.

In 1993, Mardis joined the faculty of Washington University School of Medicine. Over the next 23 years, she held several and academic and leadership roles at the University, including serving as co-director of the McDonnell Genome Ins*ute. In that position, she contributed substantially to the sequencing and *ysis of the human genome, and was instrumental in establishing the utility of m*ively parallel sequencing technologies for understanding cancer biology. Her work in cancer genetics and genomics has provided insights into the genetic drivers of many types of cancer, including acute myeloid leukemia, breast cancer, glioblastoma, and lung adenocarcinoma. By better defining the landscape of germline and somatic alterations, this research helps drive new strategies for treating cancer, and is central to the concept of precision medicine.

Since joining Nationwide Children's Hospital in 2016, Dr. Mardis has turned the focus of her research to the incorporation of next-generation sequencing *ays and established knowledge about cancer genomics into clinical and therapeutic decision-making, and into the design of new approaches to cancer immunotherapy.

In 2015, Mardis helped launch an open access, precision medicine journal, Molecular Case Studies, in conjunction with Cold Spring Harbor Laboratory Press. She currently serves as Editor-in-Chief. In 2020 she was Deputy Editor-in-Chief of Disease Models & Mechanisms journal, with Elizabeth Patton the Editor-in-Chief.

Mardis was elected as president of the American *ociation for Cancer Research for 2019–2020.

Awards and honors

• 2010: Scripps Translational Research Award
• 2011: Distinguished Alumna Award from the College of Arts and Sciences, Oklahoma University
• 2016: Morton K. Schwartz Award for Significant Contributions in Cancer Research Diagnostics from the American *ociation for Clinical Chemistry
• 2017: Precision Medicine World Congress 2017 Luminary Award
• 2019: Elected to the 2019 cl* of Fellows of the American *ociation for Cancer Research (AACR) Academy

References

External links

• McDonnell Ins*ute Bio
• PubMed Citations
• "Elaine Mardis and Richard Wilson: Taking Cancer's Genetic Measure." US News & World Report. 30 June 2009.
• "Revolutionizing cancer care with next-generation sequencing: an interview with Elaine Mardis." Disease Models & Mechanisms 2014 7: 313-317; doi: 10.1242/dmm.015396
• "Genetic Clues to Cancer's Spread." Technology Review. 14 April 2010.
• "Washington University Team Sequences AML Relapse Tumor." GenomeWeb Daily News. 12 May 2010.
• Nature Podcast. 15 April 2010.
• "A Conversation about Sequencing Cancer Genomes with Dr. Elaine Mardis." NCI Cancer Bulletin. 26 January 2010.