American physician and researcher

Betty Diamond (born 11 May 1948, in Hartford, Connecticut) is an American physician and researcher. She is director of the Ins*ute of Molecular Medicine at Northwell Health's Feinstein Ins*ute for Medical Research in Manh*et, NY. She was elected a member of the National Academy of Sciences in 2022.

Contents

• 1 Education
• 2 Academic career
• 3 Research
• 4 Awards and honors
• 5 References

Education

Betty Diamond received her B.A. in Art History (Magna *) from Radcliffe College in 1969 and her M.D. from Harvard Medical School in 1973. In 1976 she began her residency at Columbia Presbyterian Medical Center, New York, NY and in 1979 embarked on post-doctoral fellowship in Immunology with Dr. Matthew Scharff at the Albert Einstein College of Medicine, Bronx, NY.

Academic career

Diamond has been on the faculty and chief of rheumatology at both Einstein and Columbia. She is currently head of the Center for Autoimmune and Musculoskeletal Disease at The Feinstein Ins*ute for Medical Research and Professor of Molecular Medicine at Hofstra Northwell School of Medicine. She has been on the board of the American College of Rheumatology, is past president of the American *ociation of Immunology, and is a member of the Ins*ute of Medicine. She is also past chair of the scientific advisory board of the National Ins*ute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) and has been on their Scientific Council.

Research

Diamond's primary interests are in the mechanisms of central and peripheral tolerance of autoreactive B cells, and the defects in these mechanisms that are present in autoimmune disease, as well as the role of antibodies in brain disease. Diamond identified the first idiotype marker on anti-DNA antibodies in patients with lupus, and discovered that anti-DNA antibodies in patients and mice shared characteristics with antibodies to pneumococcal polysaccharide. Diamond showed that a single base change in a protective anti-pneumococcal antibody could convert it into a potentially pathogenic anti-DNA antibody. She also found that a peptide that binds to 50% of anti-DNA antibodies in lupus patients and mice represents an epitope on glutamate receptors of the brain and can destroy neurons. Antibodies against the epitope are present in the cerebrospinal fluid and in brain tissue of patients with neuropsychiatric lupus. Her work provides a mechanism for aspects of neuropsychiatric lupus, and more generally for acquired changes in cognition and behavior. Diamond also studies the role that hormones may play in the development of lupus.

Awards and honors

(from 2000–present):

• Scientific Leadership Award, SLE Lupus Foundation, 2000
• Outstanding Investigator Award of the ACR, 2001
• Lee Howley Award from the Arthritis Foundation, 2002
• Recognition Award from the National *ociation of MD-PhD Programs, 2004
• Honorary Alumna Award, Albert Einstein College of Medicine, 2004
• Klemperer Award New York Academy of Medicine and Arthritis Foundation (NY Chapter), 2004
• Klemperer award, American College of Rheumatology Ins*ute of Medicine, 2005
• Ins*ute of Medicine, 2006
• Fellow, AAAS, 2006
• Evelyn V. Hess research Award, Lupus Foundation of America, Inc., 2008
• American College of Rheumatology Mentor Award 2011

References