Simone Weiler (née Karn, 16 December 1978) is a German swimmer who won a gold medal in the 4×100 m medley relay at the 2002 European Aquatics Championships (50 m pool). She also won three bronze medals in breaststroke in 2003–2005 at short-course (25 m pool) European championships. She competed at the 2000 Summer Olympics in the 100 m breaststroke but failed to reach the final. Between 2001 and 2002 she won four national *les in breaststroke events. Around 2000–2001 she married and changed her last name from Karn to Weiler.

After retirement from senior swimming she competed in the masters category.

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